Sequencher

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Click here to download CodeLinker 1.0. This will provide you with the full functionality of CodeLinker for your RNA-Seq and microarray analysis needs until September 30, 2017.

 

 

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Pathology

The growth of molecular pathology as a discipline has accelerated dramatically since the introduction of Sanger sequencing in the late 1970’s, followed by the technological advances culminating today in what is termed Next-Generation Sequencing. Whether the actual application is in plant, animal, or human disease, or the focus is on a virological, microbiological, or mutational causation, sequencing is a powerful and discriminating tool which can provide essential insights.

Assembly

Assembly

Sequencher has built its reputation on proprietary DNA sequence assembly algorithms that have set the standard in research labs across the world for over 25 years.  No other program gives you such a comprehensive set of science-driven features that can fit almost any project and get results fast. 

Sequencher has several different assembly algorithms as well as different assembly modes providing the flexibility to work with any of kind sequence data. 

Genetics

With the advent of DNA sequencing, the study of genetics took a major leap forward as this enabling technology entered every day usage. Studying the mechanisms of inheritance of normal and mutated genes became possible at the single base level. You may be studying single gene or complex traits in humans or population studies in plants or animals. Whatever you are studying, the bottleneck since the invention of DNA sequencing has remained the same, it is not in generating the data but in analysing it.

Sequencher Slideshow button

Submitted by admin on Wed, 08/03/2016 - 07:25

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Sanger DNA Analysis

Submitted by admin on Wed, 08/03/2016 - 07:24

Dendrimers and Polyamino-Phenolic Ligands: Activity of New Molecules Against Legionella pneumophila Biofilms

Dendrimers and Polyamino-Phenolic Ligands: Activity of New Molecules Against Legionella pneumophila Biofilms Forward and reverse sequences were analyzed and assembled using Sequencher 5.2.4 (Gene Codes Corporation, Ann Arbor, MI, USA) and blasted against Ribosomal Database Project (Cole et al., 2013).

Molecular findings of Colombian patients with type VI mucopolysaccharidosis (Maroteaux–Lamy syndrome)

The program Sequencher 5.2.4 (Gene Codes Corporation) was used for sequence analysis. Upon discovery of any discrepancy between the reference sequence (NG_007089.1) and a patient's sequence, a search was conducted at the National Center for Biotechnology Information (NCBI) database (http://www.ncbi.nlm.nih.gov/gene/411) to determine whether the variant had been previously reported.     

Hepatitis B Infection, Viral Load and Resistance in HIV-Infected Patients in Mozambique and Zambia

DNA was purified using QIAquick PCR purification kit (Qiagen, Hilden, Germany). Sanger sequencing was performed using an AB3130 genetic analyzer (Life Technologies, California, USA) and nucleotide sequences analyzed with Sequencher version 5.0 (Gene Codes Corporation, Michigan, USA). 

CRISPR/Cas9-mediated gene knockout in the mouse brain using in utero electroporation

Additionally, mapped reads with soft-clipping information were extracted from the bam file as sequence candidates with large indels. To detect large indels, the soft-clipped reads were realigned using a large gap assembly algorithm in Sequencher 5.1 (Gene Codes Corp., Ann Arbor, MI).  

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